CTAHR NEWS

On-Target Genome Editing

Study aimed at children’s diseases could help boost agricultural production

On-Target Genome Editing

A recent study from St. Jude Children’s Research Hospital describes a new method for genome editing that could lead to safer, more targeted strategies for treating life-threatening diseases such as some cancers and blood diseases—with less risk of unwanted mutations.

The method “could help speed the transition of genome editing to clinical use, potentially curing a greater number of patients with what are currently intractable congenital diseases and conditions,” says co-researcher Yanghua He, who recently joined CTAHR’s Dept. of Human Nutrition, Food and Animal Sciences from St. Jude.

Small abnormalities in the DNA in a human genome, whether inherited or acquired, can lead to cancer and other diseases. Gene-editing technologies like CRISPR-Cas9 can repair some of these abnormalities, opening up many far-reaching possibilities for treatment.

However, safer and more specific strategies are necessary to avoid creating accidental mutations through the editing process itself. This is where “CHANGE-seq,” the new procedure created by Yanghua and her colleagues, comes in.

The co-authors developed a new method for identifying regions in the genome where the gene-editing process is more likely to misidentify the intended target site. CHANGE-seq, or “circularization for high-throughput analysis of nuclease genome-wide effects by sequencing,” can therefore help researchers figure out whether sites are “on target”—the appropriate ones to be edited—or “off target”—such that editing them could lead to accidental mutations.

This refinement of the gene-editing process has implications beyond repairing mutated genetic sites. It could also be used to modify characteristics in plant and animal species, potentially creating improved yield, greater nutritional value, or increased tolerance to environmental stresses such as drought.

“CHANGE-seq offers the promise of safely accelerating genetic engineering for animal and plant production to relieve the food shortage problem in the world,” Yanghua says. “I envision a benefit to agricultural development in Hawai’i through better methods for interpreting and predicting the unintended effects of gene editing. I hope this will inspire confidence in the safety of the next generation of promising genome-editing applications.”

Read the full study, “CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity.”

Print
Categories: CTAHR Home Page
Tags:

Giant Candy Canes

“Kō: Ethnobotanical Guide to Hawaiian Sugarcane Cultivars” gives a fascinating history

Ready, Set, Students

No in-class? No problem. ASAO is keeping CTAHR students in the loop

Helping 500,000+

The 2020 AUW Campaign targets Hawaiʻi residents who need assistance

A.I. in Ag

New grant opportunity is due October 5

Beyond Beginners

GoFarm Hawaiʻi consults on business plans, grant writing, and a whole lot more.

Vegan Leather

FDM students hope to establish sustainable manufacturing in Hawaiʻi

One Busy Man

Extension agent is helping livestock producers, near and far

$1.5M for Ag Ed

Grant designed to expand education for Native Hawaiians

Primed for Expansion

NIFA awards almost $1M to CTAHR’s Center for Tropical and Subtropical Aquaculture

Textbook Nutrition

Food Science and Human Nutrition’s latest edition adds an interactive layer

Welcome, Rock

Dr. Zhi-Yan Du joins MBBE

Men’s Wear

FDM professor is featured in a new book on masculine clothing

A Virtual Garden

The American Society for Horticultural Science’s online conference is a hit

RU AgCurious?

GoFarm Hawaiʻi Windward kicks off another farmer training

Giant Smiles

4-H contest gets keiki excited about agriculture

Safe You, Safe Campus

IT Services’ new app is mandatory for those coming to UH

Earth Mother

UH Center for Hawaiian Studies’ webinar is tonight at 7:00 p.m.

Not-Fun Spoofing

Beware of attackers impersonating CTAHR IT staff

Mission: Possible

Dean Comerford hosts a virtual Town Hall for Alumni and Friends

Conserving Kāhuli

Can structured decision-making save the Hawaiian Tree Snail?

Renaissance Agent

Molokaʻi Extension welcomes Marshall Joy

Positioned for Growth

Thesis explores a clonal rootstock program for cacao in Hawaiʻi

Bad Seed

USDA investigates packages of unsolicited seeds from China

Fire and Rain

SOEST and CTAHR document the first hurricane to cause both flooding and multiple fires.

Bringing UH to Cambodia

FCS joins a $1 million project to study socioeconomic and environmental shifts.

Sweet!

Learn about Native Hawaiian sweet potato varieties

Vegetable Garden Isle

Extension agents feed the hungry with the fruits of their research

Soil Rx

Extension offers conference on soil health

Mama Cows

Agent offers webinar on choosing heifers for cow/calf producers

Fashion Fights COVID

FDM alumna’s fashion-forward scrubs benefit Hawaiʻi Food Bank

12345678910Last